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KMID : 0386819940040020055
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Journal of the Institute of Health Environmental Sciences
1994 Volume.4 No. 2 p.55 ~ p.70
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The Progress of Biological Markers of Viral Hepatitis by Literature Review
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Abstract
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It becomes more important to apply biological markers to epidemiology, That's firstly because molecular biology has been deveolped since 1980's and secondly because the need to health service has been changing to prevention-oriented approach. I
reviewed
journals to give information on biological markers of viral hepatitis whose prevalence rate is relatively high in Korea.
@ES The results are as follows;
@EN 1. HAV antigen was discovered in 1973 and its biological markers are thymol turbidity, Clq-binding, SGOT level, rA, IgM antibody, neutralizing antibody, and human Mx protein. Human Mx protein in the most sensitive marker among them.
2. The research on HBV has been conducted since Blumberg reported HBV hepatitis in 1965. The biological markers of HBV are HBsAg, DNA polymerase HBsAg and IgM, e antigen, polymerized HSA, HBeAg, HBcAg, anti-HBc, anti-HBs, HBV DNA, X antigen,
anti-HBx,
and anti-pol, etc. Every biological marker has their own meaning.
3. There are biological markers of hepatitis C such as neopterin level, anti-HCV response to complex of core, N53, and c100 antigen, c33 c, IgM anti-capsid antibody, anti-GOR, and HCV RNA. HCV RNA is the most useful because it is detected in the
early
period of infection.
4. Biological markers of delta virus are not many. IgM antibody, IgA antibody, HDV RNA, and cDNA and ssRNA can be used to detect delta hepatitis.
5. The research on biological markers of hepatitis E has rarely been done.
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KEYWORD
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